Scientists have found evidence that tamoxifen, the drug widely used to treat breast cancer, may lose its effectiveness over time and begin to behave like the hormone it is supposed to block. Tamoxifen works by blocking the action of estrogen and keeping it from attaching to a receptor on the surface of the cell.
Researchers at Duke University Medical Center have found that after a period of two to five years, the "anti-estrogen effect of tamoxifen fades, often allowing estorgen-sensitive cancers to start growing again." The primary author of the study, John D. Norris, explained that "over time, the drug causes the estrogen receptor on cells to change and form a pocket-like structure that allows other proteins to bind there. The action of these proteins somehow changed the cellís reaction to tamoxifen. The drug converts from an anti-estrogen effect to a pro-estrogen effect."
However, the scientists have discovered that the action can be reversed with the use of peptides. They also believe that this will allow them the opportunity to find a new drug anti-estrogen drug that does not have the same effects as tamoxifen
Media Resources: Nando Times and Reuters - July 29, 1999
12/11/2013 Human Rights Day Celebrated Around The World - Yesterday marked International Human Rights Day, a day to celebrate human rights advances and to assess the challenges that lie ahead in protecting them.
"The fundamentals for protecting and promoting human rights are largely in place: these include a strong and growing body of international human rights law and standards, as well as institutions to interpret the laws, monitor compliance and apply them to new and emerging human rights issues," said United Nations High Commissioner for Human Rights Navi Pillay in a statement. . . .
12/11/2013 UConn Under Federal Investigation For Mishandling Sexual Assault Cases - The US Department of Education's Office for Civil Rights (OCR) informed the University of Connecticut on Monday that it will investigate the school for allegedly mishandling sexual assault cases and violating Title IX, the federal law that requires all recipients of federal financial assistance for education programs and activities to prohibit sex discrimination and sexual harassment [PDF].
The investigation was sparked after seven women filed a formal complaint in October alleging that UConn had failed to protect them from sexual assault and exposed them to a sexually hostile environment.One woman says her attacker was expelled from campus but later readmitted without her knowledge. . . .
12/11/2013 Massachusetts Democrat Katherine Clark Wins Congressional Seat - Democrat Katherine Clark will become the fifth woman to represent Massachusetts in the US House Tuesday, after easily defeating three opponents in a special election.
"Six years ago, there wasn't a single woman representing Massachusetts in Congress," said Niki Tsongas, the only other woman representing Massachusetts in the House. . . .