Scientists have found evidence that tamoxifen, the drug widely used to treat breast cancer, may lose its effectiveness over time and begin to behave like the hormone it is supposed to block. Tamoxifen works by blocking the action of estrogen and keeping it from attaching to a receptor on the surface of the cell.
Researchers at Duke University Medical Center have found that after a period of two to five years, the "anti-estrogen effect of tamoxifen fades, often allowing estorgen-sensitive cancers to start growing again." The primary author of the study, John D. Norris, explained that "over time, the drug causes the estrogen receptor on cells to change and form a pocket-like structure that allows other proteins to bind there. The action of these proteins somehow changed the cellís reaction to tamoxifen. The drug converts from an anti-estrogen effect to a pro-estrogen effect."
However, the scientists have discovered that the action can be reversed with the use of peptides. They also believe that this will allow them the opportunity to find a new drug anti-estrogen drug that does not have the same effects as tamoxifen
Media Resources: Nando Times and Reuters - July 29, 1999
10/30/2014 Medication Abortion Access Threatened by Oklahoma Court Ruling - An Oklahoma state district court judge has refused to block a state law restricting medication abortion, clearing the way for the law to go into affect on November 1.
The Oklahoma Coalition for Reproductive Justice, together with a local abortion clinic in Tulsa, challenged HB 2684 in September, arguing that the law was an unconstitutional restriction on non-surgical abortion in the earliest weeks of pregnancy. . . .
10/30/2014 UPS Switches Pregnant Worker Policy Ahead of Supreme Court Case - The United Parcel Service (UPS) is changing its policy on light duty assignments for pregnant workers, even though the company will stand by its refusal to extend accommodations to a former employee in an upcoming Supreme Court case.
UPS announced on Monday in a memo to employees, and in a brief filed with the US Supreme Court, that the company will begin offering temporary, light-duty positions to pregnant workers on January 1, 2015. . . .
10/30/2014 North Dakota Medical Students Speak Out Against Measure 1 - Medical students at the University of North Dakota School of Medicine and Health Sciences are asking North Dakotans to vote no on Measure 1, a personhood measure on the state ballot this fall.
The students issued published a letter in the Grand Forks Herald stating that they opposed Measure 1 in part because they are against "the government's taking control of the personal health care decisions of its citizens." Nearly 60 UND School of Medicine students signed the letter, citing concerns over the "very broad and ambiguous language" used in the proposed amendment, which has no regard for serious and life-threatening medical situations such as ectopic pregnancies.
Measure 1 would change the North Dakota state constitution to create an "inalienable right to life" for humans "at any stage of development" - including the moment of fertilization and conception. . . .