Scientists have found evidence that tamoxifen, the drug widely used to treat breast cancer, may lose its effectiveness over time and begin to behave like the hormone it is supposed to block. Tamoxifen works by blocking the action of estrogen and keeping it from attaching to a receptor on the surface of the cell.
Researchers at Duke University Medical Center have found that after a period of two to five years, the "anti-estrogen effect of tamoxifen fades, often allowing estorgen-sensitive cancers to start growing again." The primary author of the study, John D. Norris, explained that "over time, the drug causes the estrogen receptor on cells to change and form a pocket-like structure that allows other proteins to bind there. The action of these proteins somehow changed the cellís reaction to tamoxifen. The drug converts from an anti-estrogen effect to a pro-estrogen effect."
However, the scientists have discovered that the action can be reversed with the use of peptides. They also believe that this will allow them the opportunity to find a new drug anti-estrogen drug that does not have the same effects as tamoxifen
Media Resources: Nando Times and Reuters - July 29, 1999
1/23/2015 #HeForShe Campaign Launches Pilot Effort Aimed at Institutional Equality - The United Nations' gender equality campaign #HeForShe has launched a new program called IMPACT 10X10X10.
United Nations Goodwill Ambassador Emma Watson, together with UN Women Executive DirectorPhumzile Mlambo-Ngcuka, introduced the one-year pilot effort aimed at encouraging corporations, universities, and governments to play an active role in enhancing women's empowerment and equality in Davos, Switzerland today at the World Economic Forum.
"Women need to be equal participants in our homes, societies, in our governments, and in our workplaces," Watson said.
First introduced in September, HeForShe is a solidarity movement that calls on men and boys to confront gender inequalities that face women and girls globally. . . .
1/22/2015 BREAKING: House to Vote on Abortion Coverage Ban - After they were forced to scrap plans for a 20-week abortion ban, House Republican leaders decided late last night to instead ram through a vote today on a different extreme anti-abortion bill.
House Republicans are now pushing HR 7, a bill promoted as a ban on federal funding of abortion that would actually prevent women from using their own money to purchase health insurance that includes abortion care. . . .
1/22/2015 House Cancels Abortion Ban After GOP Congresswomen Drop Support - House Republicans cancelled plans to vote on a 20-week ban on abortion after Republican Congresswomen removed their names publicly as co-sponsors of the bill.
The vote on the unconstitutional 20-week ban had originally been scheduled for today, the anniversary of Roe v. . . .