Scientists have found evidence that tamoxifen, the drug widely used to treat breast cancer, may lose its effectiveness over time and begin to behave like the hormone it is supposed to block. Tamoxifen works by blocking the action of estrogen and keeping it from attaching to a receptor on the surface of the cell.
Researchers at Duke University Medical Center have found that after a period of two to five years, the "anti-estrogen effect of tamoxifen fades, often allowing estorgen-sensitive cancers to start growing again." The primary author of the study, John D. Norris, explained that "over time, the drug causes the estrogen receptor on cells to change and form a pocket-like structure that allows other proteins to bind there. The action of these proteins somehow changed the cellís reaction to tamoxifen. The drug converts from an anti-estrogen effect to a pro-estrogen effect."
However, the scientists have discovered that the action can be reversed with the use of peptides. They also believe that this will allow them the opportunity to find a new drug anti-estrogen drug that does not have the same effects as tamoxifen
Media Resources: Nando Times and Reuters - July 29, 1999
11/25/2014 Marissa Alexander Has Accepted a Plea Deal - Marissa Alexander, the woman imprisoned for firing a warning shot in the presence of her abusive husband, chose to accept a plea deal Monday with the state of Florida, pleading guilty to three felony counts of aggravated assault.
As part of the plea deal, Alexander received three years imprisonment, but she will be credited for the time she's spent behind bars. . . .
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Councilwoman Tina Ward-Pugh introduced the resolution, which passed overwhelmingly on November 6. . . .